Other than being used in the production of aspirin, acetic anhydride is used to convert cellulose to cellulose acetate, a key component in photographic film and other coated materials Wikipedia, Acetic anhydride, 2013. After 5 minutes if the product has not completely dissolved, add 5mL more of ethyl acetate. It has become very common as an antiplatelet to prevent blood clot formation and is used to prevent heart attacks and strokes. Like all catalysts, enzymes work. Sensors and Equipment This experiment features the following Vernier sensors and equipment. Another factor that could have caused a low percent yield was that when no crystals formed after adding drops of petroleum ether we placed our 25 mL Erlenmeyer flask back on the hot plate at 125 degrees Celsius.
Some parts of the site may not work properly if you choose not to accept cookies. Acetylsalicylic acid, also known as aspirin, is one of the most widely used medications to reduce fever and is also used as a pain killer. Those two chemicals are mixed together along with sulfuric acid to form a crude solid. Isolation was done through suction filtration, white, sugar-like crystals were obtained. Another way the purity of the sample is tested is through a melting point test on the purified aspirin product. This addition of cold water is very important in purification and isolation of the crystals from the liquid since aspirin is insoluble in cold water. Yard 55 chem 3341-111 The Preparation of Aspirin The purpose of this experiment is to synthesize aspirin acetyl salicylic acid from salicylic acid and acetic anhydride.
While waiting for the sample to vacuum dry weigh a weigh boat. The report is divided into several well-defined sections. When atoms or ions in ground state are heated to a higher temperature, some electrons absorb enough energy to move them to higher energy levels. After the mixture has heated for 10 minutes, remove it from the water bath and allow it to cool to room temperature. He also synthesized Aspirin because his father, who had severe arthritis, could not tolerate the salicylic acid he was taking for pain relief. Acetic acid, Aspirin, Bayer 1426 Words 5 Pages Synthesis of Aspirin Name: Xuanyi Li Teaching assistant: Deirdre Zwilling November 15, 2009 Purpose: To synthesize aspirin, a common analgesic drug, via nucleophilic acid-catalyzed substitution reaction of salicyclic acid with acetic anhydride.
The experimental boiling point range of acetylsalicylic acid was found to be 130-132° C. Allow the sample to vacuum dry for 5 minutes. This Lab shows how better the electronic measurement. While the mixture in the flask cooled, a vacuum filtration system was created, and once crystallization occurred, the mixture was poured through the system so as to pull the liquid in the mixture through to the flask, leaving white, powdery crystals on the filter paper. The true melting point of acetylsalicylic acid is 135° C, therefore our percent.
The paper was moistened with distilled water. Then, a vacuum filtration apparatus was set up. Step 4 The molarity of the acid solution for each trial was calculated. The solid aspirin product was trapped by the filter and the liquid was drawn through the funnel into the flask below it by a vacuum. It also reduces inflammation and may even prevent heart attacks. Ferric Chloride Test for Purity Chemical Reagents:. The whole reaction is catalyzed by phosphoric acid.
A pure compound has a specific range in which it melts and it is normally a fairly small range. Only a few elements on the periodic table are nonmetals: C, N, O, S, Cl, and F. The limiting reactant of the equation was salicylic acid. Your two primary objectives in this experiment will be to synthesize and analyze aspirin. It has the ability to reduce fever an antipyretic , to reduce pain an analgesic , and to reduce swelling, soreness, and redness an anti-inflammatory agent.
Before recrystallisation the crude aspirin could of included. All objectives were performed successfully. It has been present for over one hundred years and is one of the most widely used medications in the world. The findings showed that acetylsalicylic acid can be produced through a reaction between salicylic acid and acetic anhydride, but that a much lower yield will be produced. The crystal product will be stuck at the top of the capillary tube. The colors of each test tube were recorded in a data table.
Analgesics are a group of pain relieving drugs designed to eliminate pain and inflammation by acting on the peripheral and central nervous systems. Because it is easy to prepare, aspirin is one of the most inexpensive drugs available. Fill bottle with Distilled water. Moving into Lab 2, our lab group was tasked with producing and standardizing an approximately. Inaccurate calibrations of the hot plate or balance could have shown higher or lower quantitative data which would have affected the results by producing either a higher or lower percent yield.
The initial step of the experimental process was the synthesis of Aspirin, which required the reaction of salicylic acid, acetic anhydride, and phosphoric acid to produce aspirin and acetic acid. . Introduction: A polymer consists of repeating subunits in the form of —A-A-A-A-A- or A-B-A-B-A-B-, where A and B are different subunits. An analgesic is a member of the group of drugs used to achieve analgesia, which is the relief from pain. The melting point of the purified product was lower than the expected 135 degree Celsius melting point of aspirin, which revealed to us that the purified aspirin product still contained some impurities. Step 5 The starting volume on the burette was recorded. Place the Erlenmeyer flask in an ice bath for 30 minutes.
Next a melting point test was performed on the purified aspirin product. Place the flask into the 70°C water bath and heat for 10 minutes 6. Discussion: Mechanism: Reaction 2 Vanillin H2O2 Divanillin 2 H2O. If no aspirin forms in the liquid that went through the filter dispose the filtrate in the sink While Amanda filters the Aspirin crystals. The results of the melting point test were that our purified aspirin product started melting at 86 degrees Celsius and at 102 degrees Celsius the entire purified aspirin product had completely melted. The active metabolite ingredient in acetylsalicylic acid aspirin is salicylic acid Wikipedia, Salicylic acid, 2013 , which was first discovered by Edward Stone in 1763 Wikipedia, Aspirin, 2013.